Gravimetric Dilution / Solvent Addition
Precise gravimetric dilution for accurate concentration control.
Application Overview
Gravimetric dilution is a structured workflow combining analytical weighing with controlled solvent addition to achieve defined sample concentrations. It is widely used in analytical laboratories where precise and reproducible preparation is essential.
In a typical process, the empty tube or vial is first weighed to determine its tare value. The sample material is then added manually by the operator outside the system. After reintroducing the tube, the gross weight is measured automatically and the system calculates the exact net sample mass.
Based on this calculated sample mass, a predefined solvent volume is dispensed to achieve the desired concentration. This eliminates manual calculations and reduces variability during sample preparation.
The integration of tare weighing, net mass determination and automated solvent addition creates a reproducible, traceable and concentration-controlled workflow that significantly improves reliability in quantitative analytical applications such as HPLC preparation, digestion or extraction procedures.
Typical Use Cases
HPLC Sample Preparation
- Gravimetric determination of sample mass
- Defined solvent addition for target concentration
- Reproducible preparation of analytical samples
- Reduced manual calculation errors
Preparation of Calibration Standards
- Accurate mass-based preparation of reference solutions
- Defined dilution for concentration control
- Reproducible generation of standard curves
Pharmaceutical Quality Control
- Gravimetric preparation of active ingredient solutions
- Controlled and documented concentration workflows
- Reduced operator influence in regulated environment
Sample Digestion and Extraction Workflows
- Precise sample mass determination prior to digestion
- Defined solvent or reagent addition
- Improved reproducibility of analytical results
Environmental and Water Analysis
- Accurate preparation of environmental samples
- Defined dilution prior to chromatographic analysis
- Consistent and traceable workflow execution
Research and Development Laboratories
- Flexible concentration adjustment based on measured sample mass
- Automated solvent addition without manual recalculation
- Reliable experimental reproducibility
Workflow Description
Key Benefits
Tare and Gross Weighing Integration
Automated determination of tare and gross weight enables precise calculation of the net sample mass.
Mass-Based Concentration Control
Solvent volume is defined based on measured sample mass to achieve accurate and reproducible target concentrations.
Elimination of Manual Calculations
Automated calculation of dilution parameters reduces arithmetic errors and operator variability.
Integrated Weighing and Dispensing Workflow
Seamless combination of analytical weighing, optional decapping and controlled liquid dispensing within one structured process.
Reproducible and Documented Results
All weighing values, calculated masses and dispensing parameters are automatically recorded for full traceability.
Flexible Workflow Configuration
Predefined process parameters allow adaptation to different solvent types, concentration targets and analytical requirements.
Supported by LABOTIQ Systems
